Related Publications


  1. Busatto S, Pham A, Suh A, Shapiro S, Wolfram J. Organotropic drug delivery: Synthetic nanoparticles and extracellular vesicles.Biomed Microdevices. 2019 Apr 15;21(2):46. [PUBMED]
  2. Li J, Mai J, Hinkle L, Lin D, Zhang J, Liu X, Ramirez MR, Zu Y, Lokesh G, Volk DE, and Shen H. Tracking biodistribution of myeloid-derived cells in murine models of breast cancer. Genes 2019; 10: 297. [PMC6523772] [PUBMED]
  3. Zhang J, Mai J, Li F, Shen J, Zhang G, Li J, Hinkle LE, Lin D, Liu X, Li Z, Wang RF, Mittendorf EA, Ferrari M, Shen H. Investigation of parameters that determine Nano-DC vaccine transport. Biomed Microdevices. 2019 Apr 4;21(2):39. [PUBMED]
  4. Cruz VH, Arner EN, Du W, Bremauntz AE, Brekken RA. Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer. JCI Insight. 2019 Apr 2;5. pii: 126117. [PMC6538328] [PUBMED]
  5. Yang Z, Jiang S, Li F, Qiu Y, Gu J, Pettigrew RI, Ferrari M, Hamilton DJ, Li Z. Single-Molecule Force Measurement Guides the Design of Multivalent Ligands with Picomolar Affinity. Angew Chem Int Ed Engl. 2019 Apr 8;58(16):5272-5276.  [PMC6503962] [PUBMED]
  6. Zhang Y, Kirane A, Huang H, Sorrelle NB, Burrows FJ, Dellinger MT, Brekken RA. Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer. Mol Cancer Res. 2019 Feb;17(2):348-355. [PMC6359969] [PUBMED]
  7. Sorrelle N, Ganguly D, Dominguez ATA, Zhang Y, Huang H, Dahal LN, Burton N, Ziemys A, Brekken RA. Improved Multiplex Immunohistochemistry for Immune Microenvironment Evaluation of Mouse Formalin-Fixed, Paraffin-Embedded Tissues. J Immunol. 2019 Jan 1;202(1):292-299. [PMC6310091][PUBMED]
  8. Li X, Lee Y, Kang Y, Dai B, Perez MR, Pratt M, Koay EJ, Kim M, Brekken RA, Fleming JB. Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma. Cell Death Differ. 2019 Jan;26(2):382-393. [PMC6329841] [PUBMED]


  1. Ziemys A, Yokoi K, Kai M, Liu YT, Kojic M, Simic V, Milosevic M, Holder A, Ferrari M.Progression-dependent transport heterogeneity of breast cancer liver metastases as a factor in therapeutic resistance. J Control Release. 2018 Dec 10;291:99-105.  [PMC6501216] [PUBMED]
  2. Chen HM, van der Touw W, Wang YS, Kang K, Mai S, Zhang J, Alsina-Beauchamp D, Duty JA, Mungamuri SK, Zhang B, Moran T, Flavell R, Aaronson S, Hu HM, Arase H, Ramanathan S, Flores R, Pan PY, Chen SH. Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity. J Clin Invest. 2018 Dec 3;128(12):5647-5662. [PMC6264729] [PUBMED]
  3. Koay EJ, Lee Y, Cristini V, Lowengrub JS, Kang Y, Lucas FAS, Hobbs BP, Ye R, Elganainy D, Almahariq M, Amer AM, Chatterjee D, Yan H, Park PC, Rios Perez MV, Li D, Garg N, Reiss KA, Yu S, Chauhan A, Zaid M, Nikzad N, Wolff RA, Javle M, Varadhachary GR, Shroff RT, Das P, Lee JE, Ferrari M, Maitra A, Taniguchi CM, Kim MP, Crane CH, Katz MH, Wang H, Bhosale P, Tamm EP, Fleming JB. A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma. Clin Cancer Res. 2018 Dec 1;24(23):5883-5894. [PMC6279613] [PUBMED]
  4. Du W, Brekken RA. Does Axl have potential as a therapeutic target in pancreatic cancer? Expert Opin Ther Targets. 2018 Nov;22(11):955-966. [PMC6292430] [PUBMED]
  5. Du W, Huang H, Sorrelle N, Brekken RA. Sitravatinib potentiates immune checkpoint blockade in refractory cancer models. JCI Insight. 2018 Nov 2;3(21) [PMC6238734] [PUBMED]
  6. Elganainy D, Holliday EB, Taniguchi CM, Smith GL, Shroff R, Javle M, Raghav K, Kaseb A, Aloia TA, Vauthey JN, Tzeng CD, Herman JM, Koong AC, Krishnan SX, Minsky BD, Crane CH, Das P, Koay EJ. Dose escalation of radiotherapy in unresectable extrahepatic cholangiocarcinoma. Cancer Med. 2018 Oct;7(10):4880-4892. [PMC6198206] [PUBMED]
  7. Mu C, Wu X, Zhou X, Wolfram J, Shen J, Zhang D, Mai J, Xia X, Holder AM, Ferrari M, Liu X, Shen H. Chemotherapy Sensitizes Therapy-Resistant Cells to Mild Hyperthermia by Suppressing Heat Shock Protein 27 Expression in Triple-Negative Breast Cancer. Clin Cancer Res. 2018 Oct 1;24(19):4900-4912. [PMC6168413] [PUBMED]
  8. Kojic M, Milosevic M, Simic V, Koay EJ, Kojic N, Ziemys A, Ferrari M. Multiscale smeared finite element model for mass transport in biological tissue: From blood vessels to cells and cellular organelles. Comput Biol Med. 2018 Aug 1;99:7-23. [PMC6441961] [PUBMED]
  9. Ng SP, Koay EJ. Current and emerging radiotherapy strategies for pancreatic adenocarcinoma: stereotactic, intensity modulated and particle radiotherapy. Ann Pancreat Cancer. 2018 Aug;1. pii: 22.: [PMC6124686] [PUBMED]
  10. Milosevic M, Simic V, Milicevic B, Koay EJ, Ferrari M, Ziemys A, Kojic M. Correction function for accuracy improvement of the Composite Smeared Finite Element for diffusive transport in biological tissue systems. Comput Methods Appl Mech Eng. 2018 Aug 15;338:97-116. [PMC6292687] [PUBMED]
  11. Wang F, Xia X, Yang C, Shen J, Mai J, Kim HC, Kirui D, Kang Y, Fleming JB, Koay EJ, Mitra S, Ferrari M, Shen H. SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy. Clin Cancer Res. 2018 Jul 1;24(13):3176-3185. [PMC6345154] [PUBMED]
  12. Mai J, Li X, Zhang G, Huang Y, Xu R, Shen Q, Lokesh GL, Thiviyanathan V, Chen L, Liu H, Zu Y, Ma X, Volk DE, Gorenstein DG, Ferrari M, Shen H. DNA Thioaptamer with Homing Specificity to Lymphoma Bone Marrow Involvement. Mol Pharm. 2018 May 7;15(5):1814-1825. [PMC6311132] [PUBMED]
  13. Nizzero S, Ziemys A, Ferrari M. Transport Barriers and Oncophysics in Cancer Treatment. Trends Cancer. 2018 Apr;4(4):277-280. [PMC6441955] [PUBMED]
  14. Amer AM, Zaid M, Chaudhury B, Elganainy D, Lee Y, Wilke CT, Cloyd J, Wang H, Maitra A, Wolff RA, Varadhachary G, Overman MJ, Lee JE, Fleming JB, Tzeng CW, Katz MH, Holliday EB, Krishnan S, Minsky BD, Herman JM, Taniguchi CM, Das P, Crane CH, Le O, Bhosale P, Tamm EP, Koay EJ. Imaging-based biomarkers: Changes in the tumor interface of pancreatic ductal adenocarcinoma on computed tomography scans indicate response to cytotoxic therapy. Cancer. 2018 Apr 15;124(8):1701-1709. [PMC5891375] [PUBMED]
  15. Koay EJ, Hall W, Park PC, Erickson B, Herman JM. The role of imaging in the clinical practice of radiation oncology for pancreatic cancer.Abdom Radiol (NY). 2018 Feb;43(2):393-403. [PMC5832555] [PUBMED]
  16. Zhu M, Ding X, Zhao R, Liu X, Shen H, Cai C, Ferrari M, Wang HY, Wang RF. Co-delivery of tumor antigen and dual toll-like receptor ligands into dendritic cell by silicon microparticle enables efficient immunotherapy against melanoma.J Control Release. 2018 Feb 28;272:72-82. [PMC5825289] [PUBMED]
  17. Kojic M, Milosevic M, Kojic N, Koay EJ, Fleming JB, Ferrari M, Ziemys A. Mass release curves as the constitutive curves for modeling diffusive transport within biological tissue. Comput Biol Med. 2018 Jan 1;92:156-167. [PMC5927384] [PUBMED]
  18. Tang C, Hobbs B, Amer A, Li X, Behrens C, Canales JR, Cuentas EP, Villalobos P, Fried D, Chang JY, Hong DS, Welsh JW, Sepesi B, Court L, Wistuba II, Koay EJ. Development of an Immune-Pathology Informed Radiomics Model for Non-Small Cell Lung Cancer. Sci Rep. 2018 Jan 31;8(1):1922. [PMC5792427][PUBMED]
  19. Liu H, Mai J, Shen J, Wolfram J, Li Z, Zhang G, Xu R, Li Y, Mu C, Zu Y, Li X, Lokesh GL, Thiviyanathan V, Volk DE, Gorenstein DG, Ferrari M, Hu Z, Shen H. A Novel DNA Aptamer for Dual Targeting of Polymorphonuclear Myeloid-derived Suppressor Cells and Tumor Cells. 2018 Jan 1;8(1):31-44.  [PMC5743458] [PUBMED]
  20. Ludwig KF, Du W, Sorrelle NB, Wnuk-Lipinska K, Topalovski M, Toombs JE, Cruz VH, Yabuuchi S, Rajeshkumar NV, Maitra A, Lorens JB, Brekken RA. Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer.Cancer Res. 2018 Jan 1;78(1):246-255. [PMC5754222] [PUBMED]


  1. Wu X, Hu Z, Nizzero S, Zhang G, Ramirez MR, Shi C, Zhou J, Ferrari M, Shen H. Bone-targeting nanoparticle to co-deliver decitabine and arsenic trioxide for effective therapy of myelodysplastic syndrome with low systemic toxicity.J Control Release. 2017 Dec 28;268:92-101. [PMC5722672] [PUBMED]
  2. Aguilera KY, Huang H, Du W, Hagopian MM, Wang Z, Hinz S, Hwang TH, Wang H, Fleming JB, Castrillon DH, Ren X, Ding K, Brekken RA. Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther. 2017 Nov;16(11):2473-2485. [PMC5669827] [PUBMED]
  3. Wolfram J, Nizzero S, Liu H, Li F, Zhang G, Li Z, Shen H, Blanco E, Ferrari M. A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery. Sci Rep. 2017 Oct 23;7(1):13738.  [PMC5653759 ] [PUBMED]
  4. Li X, Kang Y, Roife D, Lee Y, Pratt M, Perez MR, Dai B, Koay EJ, Fleming JB. Prolonged exposure to extracellular lumican restrains pancreatic adenocarcinoma growth. 2017 Sep 21;36(38):5432-5438. [PMC5799806 ] [PUBMED]
  5. Kojic M, Milosevic M, Simic V, Koay EJ, Fleming JB, Nizzero S, Kojic N, Ziemys A, Ferrari M. A composite smeared finite element for mass transport in capillary systems and biological tissue. Comput Methods Appl Mech Eng. 2017 Sep 1;324:413-437. [PMC5703437] [PUBMED]
  6. Shen H, Sun T, Hoang HH, Burchfield JS, Hamilton GF, Mittendorf EA, Ferrari M. Enhancing cancer immunotherapy through nanotechnology-mediated tumor infiltration and activation of immune cells. Semin Immunol. 2017 Sep 22. pii: S1044-5323(17)30008-8.  [PMC5705528] [PUBMED]
  7. Conlan RS, Pisano S, Oliveira MI, Ferrari M, Mendes Pinto I. Exosomes as Reconfigurable Therapeutic Systems. Trends Mol Med. 2017 Jul;23(7):636-650. [PMC5657340] [PUBMED]
  8. Samuelsson E, Shen H, Blanco E, Ferrari M, Wolfram J. Contribution of Kupffer cells to liposome accumulation in the liver. Colloids Surf B Biointerfaces. 2017 Jul 15;158:356-362. [PMC5645238] [PUBMED]
  9. Wang RF, Wang HY. Immune targets and neoantigens for cancer immunotherapy and precision medicine. Cell Res. 2017 Jan;27(1):11-37. [PMC5223235] [PUBMED]
  10. Kojic M, Milosevic M, Simic V, Koay EJ, Kojic N, Ziemys A, Ferrari M. Extension of the composite smeared finite element (CSFE) to include lymphatic system in modeling mass transport in capillary systems and biological tissue. J Serbian Soc Comput Mech. 2017;11(2):108-119. [PMC5957499] [PUBMED]
  11. Mascheroni P, Boso D, Preziosi L, Schrefler BA. Evaluating the influence of mechanical stress on anticancer treatments through a multiphase porous media model. Journal of theoretical biology. 2017; 421:179-188. [PMC5500690] [PUBMED]
  12. Persano S, Guevara ML, Li Z. Lipopolyplex potentiates anti-tumor immunity of mRNA-based vaccination. Biomaterials. 2017; 125:81-89. [PMC5378555] [PUBMED]
  13. Shen J, Wolfram J, Ferrari M, Shen H. Taking the vehicle out of drug delivery. Materials today (Kidlington, England). 2017; 20(3):95-97. [PMC5431297] [PUBMED]
  14. Ban Y, Mai J, Li X. Targeting Autocrine CCL5-CCR5 Axis Reprograms Immunosuppressive Myeloid Cells and Reinvigorates Antitumor Immunity. Cancer research. 2017; 77(11):2857-2868. [PMC5484057] [PUBMED]


  1. Xu R, Zhang G, Mai J, Deng X, Segura-Ibarra V, Wu S, Shen J, Liu H, Hu Z, Chen L, Huang Y, Koay E, Huang Y, Liu J, Ensor JE, Blanco E, Liu X, Ferrari M, Shen H. An injectable nanoparticle generator enhances delivery of cancer therapeutics. Nat Biotechnol. 2016 Apr;34(4):414-8. [PMC5070674] [PUBMED]

Earlier Publications

  1. Blanco E, Shen H, Ferrari M. Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biotechnol. 2015 Sep;33(9):941-51. [PMC4978509] [PUBMED]
  2. Koay EJ, Truty MJ, Cristini V, Thomas RM, Chen R, Chatterjee D, Kang Y, Bhosale PR, Tamm EP, Crane CH, Javle M, Katz MH, Gottumukkala VN, Rozner MA, Shen H, Lee JE, Wang H, Chen Y, Plunkett W, Abbruzzese JL, Wolff RA, Varadhachary GR, Ferrari M, Fleming JB. Transport properties of pancreatic cancer describe gemcitabine delivery and response. J Clin Invest. 2014 Apr;124(4):1525-36. [PMC3973100] [PUBMED]
  3. Physical Sciences – Oncology Centers Network., Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O’Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH. A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep. 2013;3:1449. [PMC3636513] [PUBMED]
  4. Michor F, Liphardt J, Ferrari M, Widom J. What does physics have to do with cancer? Nat Rev Cancer. 2011 Aug 18;11(9):657-70. [PMC3711102] [PUBMED]